Research

With a network of 24 scientific and industrial partners from twelve countries, MiCCrobioTAckle is uniquely positioned to run, for the first time, a trans-disciplinary and integrative approach to explore the gut microbiota’s role as the master regulator of organ-organ communication leading to cancer cachexia.

MiCCrobioTAckle’s research plan entails 12 interdisciplinary projects (one per doctoral candidate, DC), integrated in 4 thematic and interconnected work packages (WPs).

WP1 Association studies is set to identify novel gut microbiome-disease associations, which could help deduce mechanisms, biomarkers, and therapeutic hits.

WP2 Bioengineering aims to rationally develop new microbiome strains/consortia capable of producing multimodal-microbial therapeutics to combat cancer cachexia.

WP3 Causality studies in cell lines and mice models aims to validate causality and propose new mechanistic links based on native and/or bioengineered microbes.

WP4 Faecal Microbiotal Transplantation (FMT) trials is set to test accessible (oral) and high-precisions (rationally designed) FMT formulations for next-gen microbiome therapeutics.